Search Results - Therapeutics

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Selectable stem cell modification for anti-HIV gene therapy using transient cell surface marking of modified cells using Modified CD4 molecule (CD4mod)

Green fluorescent protein (GFP) is a common in vitro cell surface marker, however, when incorporated in vivo, it can lead to unwanted immune responses. This ultimately leads to their elimination by the immune system. The current technology uses modified CD4 as a cell surface marker to purify modified stem cells using immunomagnetic beads. This method...

Published: 10/11/2018 | Inventor(s): Himanshu Garg, Anjali Joshi

Keywords(s):

Category(s): Therapeutics, Life Sciences

Using glycoside hydrolases to treat biofilm-associated infections

Chronic wounds create large healthcare costs and complicate patient healing. Biofilms are a recurring cause of such wounds due to their resilience to antibiotics. Currently, there are no outstanding treatments. The standard of care is debridement followed by antibiotics, however these infections can be hard to treat because of the biofilms. This is...

Published: 9/18/2018 | Inventor(s): Kendra Rumbaugh, Derek Fleming

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Category(s): Antibiotic, Immunology, Life Sciences, Pharmaceutical, Therapeutics

Water Soluble Modified Mitochondria Division Inhibitor 1

Mitochondrial diseases are broad, they range from metabolic disorders to Huntington's diseases, Alzheimer's diseases, Parkinson's disease and schizophrenia. It is known that excessive mitochondrial division can contribute to apoptosis and therefore mitochondrial division inhibitors are an attractive therapeutic.Mitochondrial division inhibitor 1 (Mdivi-1)...

Published: 9/19/2018 | Inventor(s): P. Hemachandra Reddy, CHANDRA SEKHAR KURUVA

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Category(s): Life Sciences, Pharmaceutical, Therapeutics

Label–free, high-throughput holographic screening and enumeration of tumor cells in blood

Technology SummaryCirculating tumor cells (CTCs) are cells that have entered the peripheral blood of cancer patients after having left primary or metastatic tumors. Identifying the presence and assessing the characteristics of these CTCs through liquid biopsies has shown great promise for improving cancer patient care by enabling early cancer detection.Current...

Published: 11/29/2018 | Inventor(s): Siva Vanapalli, Dhananjay Singh, Wei Li, Caroline Ahrens

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Category(s): Assay, Cancer Diagnostics, Device, Life Sciences, Medical Device, Medical Diagnostic, Pharmaceutical, Therapeutics

Modified minocyclines for the treatment and prevention of alcohol use disorder

Technology SummaryAlcohol use disorder (AUD) affects millions of people worldwide and lacks a strong pharmaceutical option for treatment. Minocycines have been shown to have great therapeutic potential due to their positive interactions with the central nervous system, their main drawback being unwanted bactericidal effects and toxicity. This technology...

Published: 9/25/2018 | Inventor(s): Ted Reid, Susan Bergeson, Peter Syapin

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Category(s): Life Sciences, Pharmaceutical, Therapeutics

Modified Tetracycline for treatment of disorders involving potential inflammatory processes

Published: 9/19/2018 | Inventor(s): Ted Reid, Susan Bergeson, Peter Syapin

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Category(s): Life Sciences, Pharmaceutical, Therapeutics

Development of kanamycin derivatives as connexin hemichannel inhibitors

Technology SummaryConnexin hemichannel’s play a role in several disorders and diseases, including deafness, cataracts, and ischemic damage of the heart, brain, and kidneys. Aminoglycosides have been shown to inhibit these channels, but their antibiotic effects are problematic. This invention is comprised of several aminoglycoside derivatives that...

Published: 12/11/2018 | Inventor(s): Guillermo Altenberg, Cheng-Wei Chang

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Category(s): Therapeutics, Life Sciences, Pharmaceutical

New self-attenuated prophylactic and therapeutic vaccines against microbial pathogens such as influenza viruses.

Technology SummaryTypically live-attenuated viruses alter the viral genome by deletions or mutations that render the virus inert. This is a live-attenuated vaccine for influenza that incorporates microRNA's into the viral genome to attenuate viral replication. This is shown to be beneficial for several reasons including: a robust immune response, another...

Published: 9/18/2018 | Inventor(s): Mingtao Zeng, Ke Wen

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Category(s): Vaccines, Life Sciences-> Vaccines, Immunology, Life Sciences, Therapeutics

Development of Virus like particle (VLP) vaccine and reporter assay for ZIKA virus

The Zika virus outbreaks throughout the world have prompted an immediate need for a vaccine. Currently, there is not an approved vaccine to treat Zika and application of DNA based vaccines has posed severe risks, such as insertional mutagenesis. Due to these threats, the FDA is unlikely to approve DNA based vaccines.This invention has identified a...

Published: 11/29/2018 | Inventor(s): Himanshu Garg, Anjali Joshi

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Category(s): Therapeutics, Assay, Vaccines

A novel method for producing hollow exine shells from pollen grains

Pollen grains are naturally occurring microcapsules produced by plants. Hollow pollen shells have been found useful for pharmaceutical drug delivery among other uses. To be of use for these purposes, pollen shells must be emptied of their proteinaceous material. The conventional method uses an organic solvent to defatten the pollens, then applies an...

Published: 7/2/2018 | Inventor(s): Harvinder Gill, Shashwati Atwe, Pedro Gonzalez-Cruz

Keywords(s):

Category(s): Vaccines, Therapeutics

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