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New self-attenuated prophylactic and therapeutic vaccines against microbial pathogens such as influenza viruses.

Technology SummaryTypically live-attenuated viruses alter the viral genome by deletions or mutations that render the virus inert. This is a live-attenuated vaccine for influenza that incorporates microRNA's into the viral genome to attenuate viral replication. This is shown to be beneficial for several reasons including: a robust immune response, another...

Published: 9/18/2018 | Inventor(s): Mingtao Zeng, Ke Wen

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Category(s): Vaccines, Life Sciences-> Vaccines, Immunology, Life Sciences, Therapeutics

Post Exposure Vaccination for Anthrax using siRNA

Anthrax is a disease that rarely occurs naturally in humans, making it more realistic to develop a post exposure prophylaxis or therapy instead of a program of mass immunization. When the bacteria Bacillus anthracis is introduced into the body, it will later produce the anthrax toxin which affects certain receptors on the host’s cells, potentially...

Published: 11/29/2018 | Inventor(s): Mingtao Zeng

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Category(s): Vaccines

New live attenuated viral vaccine created by self-attenuation with species-specific artificial microRNA

The technology proposes a solution to the potential risks of the current Live Attenuated Influenza Vaccines (LAIV) by proposing a new mammalian-specific LAIV. This was done through the creation of a genetically-engineered influenza virus, that produces an immune response only in mammals. This attenuated vaccine produces mature and functional artificial...

Published: 11/29/2018 | Inventor(s): Mingtao Zeng, Junwei Li

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Category(s): Vaccines

Broad Spectrum Vaccine against Influenza and Anthrax

Influenza virus is a prominent seasonal pathogen with the potential to break out into pandemic disease. Despite the availability of current seasonal influenza vaccines, the virus mutates rapidly and necessitates annual re-formulation of vaccines. Anthrax, conversely, is a disease that may be prevented with a single regimen of anti-anthrax vaccine...

Published: 12/13/2018 | Inventor(s): Mingtao Zeng, Maria Arevalo, Junwei Li

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Category(s): Life Sciences-> Vaccines

A Microneedle-mediated and Nanoparticle Adjuvanted Skin Patch Genetic Vaccine against Botulism

A pain-free, easily administered and stored vaccine for protection against botulism has been developed. Administration, through the skin, using a micro-needle elicits a stronger immune response than commonly used, and frequently painful, intramuscular injections. The use of a DNA plasmid makes the vaccine quick and simple to manufacture. Together, the...

Published: 7/2/2018 | Inventor(s): Mingtao Zeng, Zhengroung Cui, Amit Kumar, Junwei Li

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Category(s): Vaccines

A New Universal Influenza Vaccine

Contemporary vaccination against the influenza virus has the distinct limitation of transient effectiveness due to the phenomenon of periodic antigenic shift by which the virus mutates to outpace vaccination. However, by targeting a different, more conserved (unchanging) area of the virus, a universal vaccine may be produced that does not need to be...

Published: 11/29/2018 | Inventor(s): Mingtao Zeng, Junwei Li

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Category(s): Vaccines

RNAi-based New Therapeutic Strategies against Anthrax

This therapeutic strategy is directed to the use of small interfering RNAs that target host factors, namely anthrax toxin receptors ANTXR1 and ANTXR2. The reduction of expression of ANTXR1 and ANTXR2 leads to the inhibition of endocytosis of anthrax toxins, which is a significant part of the toxicity mechanism. Furthermore, this strategy uses RNA interference...

Published: 12/13/2018 | Inventor(s): Mingtao Zeng, Maria Arevalo

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Category(s): Therapeutics