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Development of kanamycin derivatives as connexin hemichannel inhibitors
Technology SummaryConnexin hemichannel’s play a role in several disorders and diseases, including deafness, cataracts, and ischemic damage of the heart, brain, and kidneys. Aminoglycosides have been shown to inhibit these channels, but their antibiotic effects are problematic. This invention is comprised of several aminoglycoside derivatives that...
Published: 12/11/2018
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Inventor(s):
Guillermo Altenberg
,
Cheng-Wei Chang
Keywords(s):
Category(s):
Therapeutics
,
Life Sciences
,
Pharmaceutical
Polymer nanodiscs for biotechnology and medical applications
Membrane proteins (MP) mediate many of the cell’s fundamental processes and MPs are embedded in the cell’s membrane lipid bilayer. Currently, MPs are targets for about 60% of therapeutic drugs in use. However, MPs are very difficult to manipulate and study because they require both an aqueous environment and need transmembrane hydrophobic...
Published: 12/11/2018
|
Inventor(s):
Guillermo Altenberg
,
Hongjun Liang
Keywords(s):
Category(s):
Life Sciences
Zwitterionic Styrene–Maleic Amide Copolymers for the Preparation of Lipid and Polymer Membrane Nanodiscs
Membrane proteins (MP) mediate many of the cell’s fundamental processes and MPs are embedded in the cell’s membrane lipid bilayer. Currently, MPs are targets for about 60% of therapeutic drugs in use. However, MPs are very difficult to manipulate and study because they require both an aqueous environment and need transmembrane hydrophobic...
Published: 11/29/2018
|
Inventor(s):
Hongjun Liang
,
Guillermo Altenberg
Keywords(s):
Category(s):
Life Sciences