Search Results - assay

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Label–free, high-throughput holographic screening and enumeration of tumor cells in blood

Technology SummaryCirculating tumor cells (CTCs) are cells that have entered the peripheral blood of cancer patients after having left primary or metastatic tumors. Identifying the presence and assessing the characteristics of these CTCs through liquid biopsies has shown great promise for improving cancer patient care by enabling early cancer detection.Current...

Published: 11/29/2018 | Inventor(s): Siva Vanapalli, Dhananjay Singh, Wei Li, Caroline Ahrens

Keywords(s):

Category(s): Assay, Cancer Diagnostics, Device, Life Sciences, Medical Device, Medical Diagnostic, Pharmaceutical, Therapeutics

A Chemically Functionalized Paper-based Microfluidic Platform for Multiplex Heavy Metal Detection

Technology SummaryRecently, there has been a growing interest in the field of paper-based microfluidcs. This technology is being utilized for medical screening, point-of-care (POC) applications, and environmental monitoring. However, most of these devices still require expensive equipment or personnel. The new chemically patterned paper-microfluidic...

Published: 11/29/2018 | Inventor(s): Jungkyu Kim

Keywords(s):

Category(s): Assay, Medical Diagnostic, Device, Environmental

Sensors based on non-covalent complexes.

Technology SummarySensors that ascertain the presence of certain anionic or cationic species in an environment are critical to safety, research, medical diagnostics, and quality assurance and control. Regulation of these species in physiological mechanisms (e.g., metabolism, immune response) is necessary to prevent ailments such as cancer or diabetes....

Published: 8/31/2018 | Inventor(s): Gregory Fernandes

Keywords(s):

Category(s): Medical Diagnostic, Assay

Development of Virus like particle (VLP) vaccine and reporter assay for ZIKA virus

The Zika virus outbreaks throughout the world have prompted an immediate need for a vaccine. Currently, there is not an approved vaccine to treat Zika and application of DNA based vaccines has posed severe risks, such as insertional mutagenesis. Due to these threats, the FDA is unlikely to approve DNA based vaccines.This invention has identified a...

Published: 11/29/2018 | Inventor(s): Himanshu Garg, Anjali Joshi

Keywords(s):

Category(s): Therapeutics, Assay, Vaccines

NOVOPLATE: Pipette-integrated droplet-based nanoliter-volume well plate for bioassays

With the expansive growth of drug screening and other biological assays, there is a need for technologies that can screen drugs using minimal amounts of the compound volumes. Currently, most multi-well plates and pipetting systems are ubiquitously used for this purpose, but are difficult to scale down for use at the nano-level due to problems of volume...

Published: 9/17/2018 | Inventor(s): Siva Vanapalli, Swastika Bithi, Deepak Solomon

Keywords(s):

Category(s): Device, Assay

Biomarkers to Identify Specific Serotypes of Salmonella in Real-time

Various Salmonella strains are common food born microbes that cause disease in humans and animals. Some strains can cause intestinal infections, while others cause typhoid fever. Because of the large variety of Salmonella strains present and the different pathogenic effects of these strains, it is important to develop rapid and flexible assays that...

Published: 12/12/2018 | Inventor(s): Marie Bugarel, Guy Loneragan, Kendra Nightingale, Mindy Brashears

Keywords(s):

Category(s): Assay, Biomarker, Food Science

Development of a Phenotypic High-Content Assay to Identify Pharmacoperone Drugs for the Treatment of Primary Hyperoxaluria Type 1 by High-Throughput Screening

Hyperoxalosis is a deadly disease for which the best current therapy is dialysis or organ transplant. The underlying cause of some forms of the disease is the misrouting of a specific enzyme; alanine:glyoxylate aminotransferase (AGT) to the mitochondira inststead of the peroxisome. Pharmacoperones are small molecules that can restore proper function...

Published: 7/2/2018 | Inventor(s): Michael Conn

Keywords(s):

Category(s): Pharmaceutical, Assay