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Development of kanamycin derivatives as connexin hemichannel inhibitors

Technology SummaryConnexin hemichannel’s play a role in several disorders and diseases, including deafness, cataracts, and ischemic damage of the heart, brain, and kidneys. Aminoglycosides have been shown to inhibit these channels, but their antibiotic effects are problematic. This invention is comprised of several aminoglycoside derivatives that...

Published: 12/11/2018 | Inventor(s): Guillermo Altenberg, Cheng-Wei Chang

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Category(s): Therapeutics, Life Sciences, Pharmaceutical