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Selectable stem cell modification for anti-HIV gene therapy using transient cell surface marking of modified cells using Modified CD4 molecule (CD4mod)

Green fluorescent protein (GFP) is a common in vitro cell surface marker, however, when incorporated in vivo, it can lead to unwanted immune responses. This ultimately leads to their elimination by the immune system. The current technology uses modified CD4 as a cell surface marker to purify modified stem cells using immunomagnetic beads. This method...

Published: 10/11/2018 | Inventor(s): Himanshu Garg, Anjali Joshi

Keywords(s):

Category(s): Therapeutics, Life Sciences

Using glycoside hydrolases to treat biofilm-associated infections

Chronic wounds create large healthcare costs and complicate patient healing. Biofilms are a recurring cause of such wounds due to their resilience to antibiotics. Currently, there are no outstanding treatments. The standard of care is debridement followed by antibiotics, however these infections can be hard to treat because of the biofilms. This is...

Published: 9/18/2018 | Inventor(s): Kendra Rumbaugh, Derek Fleming

Keywords(s):

Category(s): Antibiotic, Immunology, Life Sciences, Pharmaceutical, Therapeutics

Water Soluble Modified Mitochondria Division Inhibitor 1

Mitochondrial diseases are broad, they range from metabolic disorders to Huntington's diseases, Alzheimer's diseases, Parkinson's disease and schizophrenia. It is known that excessive mitochondrial division can contribute to apoptosis and therefore mitochondrial division inhibitors are an attractive therapeutic.Mitochondrial division inhibitor 1 (Mdivi-1)...

Published: 9/19/2018 | Inventor(s): P. Hemachandra Reddy, CHANDRA SEKHAR KURUVA

Keywords(s):

Category(s): Life Sciences, Pharmaceutical, Therapeutics

Method for creating a synthetic pulse on an actor during medical simulation

Medical training and simulation methods have made progress over the years, however, the progress made fails in comparison to other fields. New and improved electronic aids have seen huge improvements for both diagnosis and treatment, but little has been developed in the way of electronic training and simulation devices. The current invention proposes...

Published: 9/19/2018 | Inventor(s): Robert Stump

Keywords(s):

Category(s): Device, Life Sciences, Medical Device, Medical Diagnostic

Label–free, high-throughput holographic screening and enumeration of tumor cells in blood

Technology SummaryCirculating tumor cells (CTCs) are cells that have entered the peripheral blood of cancer patients after having left primary or metastatic tumors. Identifying the presence and assessing the characteristics of these CTCs through liquid biopsies has shown great promise for improving cancer patient care by enabling early cancer detection.Current...

Published: 11/29/2018 | Inventor(s): Siva Vanapalli, Dhananjay Singh, Wei Li, Caroline Ahrens

Keywords(s):

Category(s): Assay, Cancer Diagnostics, Device, Life Sciences, Medical Device, Medical Diagnostic, Pharmaceutical, Therapeutics

Modified minocyclines for the treatment and prevention of alcohol use disorder

Technology SummaryAlcohol use disorder (AUD) affects millions of people worldwide and lacks a strong pharmaceutical option for treatment. Minocycines have been shown to have great therapeutic potential due to their positive interactions with the central nervous system, their main drawback being unwanted bactericidal effects and toxicity. This technology...

Published: 9/25/2018 | Inventor(s): Ted Reid, Susan Bergeson, Peter Syapin

Keywords(s):

Category(s): Life Sciences, Pharmaceutical, Therapeutics

Modified Tetracycline for treatment of disorders involving potential inflammatory processes

Published: 9/19/2018 | Inventor(s): Ted Reid, Susan Bergeson, Peter Syapin

Keywords(s):

Category(s): Life Sciences, Pharmaceutical, Therapeutics

Development of kanamycin derivatives as connexin hemichannel inhibitors

Technology SummaryConnexin hemichannel’s play a role in several disorders and diseases, including deafness, cataracts, and ischemic damage of the heart, brain, and kidneys. Aminoglycosides have been shown to inhibit these channels, but their antibiotic effects are problematic. This invention is comprised of several aminoglycoside derivatives that...

Published: 12/11/2018 | Inventor(s): Guillermo Altenberg, Cheng-Wei Chang

Keywords(s):

Category(s): Therapeutics, Life Sciences, Pharmaceutical

New self-attenuated prophylactic and therapeutic vaccines against microbial pathogens such as influenza viruses.

Technology SummaryTypically live-attenuated viruses alter the viral genome by deletions or mutations that render the virus inert. This is a live-attenuated vaccine for influenza that incorporates microRNA's into the viral genome to attenuate viral replication. This is shown to be beneficial for several reasons including: a robust immune response, another...

Published: 9/18/2018 | Inventor(s): Mingtao Zeng, Ke Wen

Keywords(s):

Category(s): Vaccines, Life Sciences-> Vaccines, Immunology, Life Sciences, Therapeutics

Polymer nanodiscs for biotechnology and medical applications

Membrane proteins (MP) mediate many of the cell’s fundamental processes and MPs are embedded in the cell’s membrane lipid bilayer. Currently, MPs are targets for about 60% of therapeutic drugs in use. However, MPs are very difficult to manipulate and study because they require both an aqueous environment and need transmembrane hydrophobic...

Published: 12/11/2018 | Inventor(s): Guillermo Altenberg, Hongjun Liang

Keywords(s):

Category(s): Life Sciences

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