Search Results - Pharmaceutical

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Using glycoside hydrolases to treat biofilm-associated infections

Chronic wounds create large healthcare costs and complicate patient healing. Biofilms are a recurring cause of such wounds due to their resilience to antibiotics. Currently, there are no outstanding treatments. The standard of care is debridement followed by antibiotics, however these infections can be hard to treat because of the biofilms. This is...

Published: 9/18/2018 | Inventor(s): Kendra Rumbaugh, Derek Fleming

Keywords(s):

Category(s): Antibiotic, Immunology, Life Sciences, Pharmaceutical, Therapeutics

Water Soluble Modified Mitochondria Division Inhibitor 1

Mitochondrial diseases are broad, they range from metabolic disorders to Huntington's diseases, Alzheimer's diseases, Parkinson's disease and schizophrenia. It is known that excessive mitochondrial division can contribute to apoptosis and therefore mitochondrial division inhibitors are an attractive therapeutic.Mitochondrial division inhibitor 1 (Mdivi-1)...

Published: 9/19/2018 | Inventor(s): P. Hemachandra Reddy, CHANDRA SEKHAR KURUVA

Keywords(s):

Category(s): Life Sciences, Pharmaceutical, Therapeutics

Label–free, high-throughput holographic screening and enumeration of tumor cells in blood

Technology SummaryCirculating tumor cells (CTCs) are cells that have entered the peripheral blood of cancer patients after having left primary or metastatic tumors. Identifying the presence and assessing the characteristics of these CTCs through liquid biopsies has shown great promise for improving cancer patient care by enabling early cancer detection.Current...

Published: 11/29/2018 | Inventor(s): Siva Vanapalli, Dhananjay Singh, Wei Li, Caroline Ahrens

Keywords(s):

Category(s): Assay, Cancer Diagnostics, Device, Life Sciences, Medical Device, Medical Diagnostic, Pharmaceutical, Therapeutics

Modified minocyclines for the treatment and prevention of alcohol use disorder

Technology SummaryAlcohol use disorder (AUD) affects millions of people worldwide and lacks a strong pharmaceutical option for treatment. Minocycines have been shown to have great therapeutic potential due to their positive interactions with the central nervous system, their main drawback being unwanted bactericidal effects and toxicity. This technology...

Published: 9/25/2018 | Inventor(s): Ted Reid, Susan Bergeson, Peter Syapin

Keywords(s):

Category(s): Life Sciences, Pharmaceutical, Therapeutics

Modified Tetracycline for treatment of disorders involving potential inflammatory processes

Published: 9/19/2018 | Inventor(s): Ted Reid, Susan Bergeson, Peter Syapin

Keywords(s):

Category(s): Life Sciences, Pharmaceutical, Therapeutics

Development of kanamycin derivatives as connexin hemichannel inhibitors

Technology SummaryConnexin hemichannel’s play a role in several disorders and diseases, including deafness, cataracts, and ischemic damage of the heart, brain, and kidneys. Aminoglycosides have been shown to inhibit these channels, but their antibiotic effects are problematic. This invention is comprised of several aminoglycoside derivatives that...

Published: 12/11/2018 | Inventor(s): Guillermo Altenberg, Cheng-Wei Chang

Keywords(s):

Category(s): Therapeutics, Life Sciences, Pharmaceutical

Chemical probes with anti-inflammatory, neuroprotective and anticancer properties

Many diseases and disorders of the brain cause swelling of brain tissue also known as neuroinflammation. Neuroinflammation is beginning to be recognized as one of the hallmark signs and disease progression factors of Alzheimer’s and Parkinson’s disease. The swelling of brain tissue can limit the amount of blood flow to areas in the brain...

Published: 11/28/2018 | Inventor(s): Nadezhda German, Constantinos Mikelis

Keywords(s):

Category(s): Pharmaceutical

Computerized Method to Optimize the Calculation of Sigma Profiles

The invention is an optimization model used to generate sigma profiles of any concerned molecule from conceptual segment numbers of the molecule and linear combination of sigma profiles of four reference solvents representing hydrophobic, polar attractive, polar repulsive, and hydrophilic conceptual segments. Reference Number: D-1089Market Applications:•...

Published: 12/4/2018 | Inventor(s): Chau-Chyun Chen, Md Islam

Keywords(s): Fine Chemicals, Pharmaceuticals, polymers, Software

Category(s): Pharmaceutical, Software

FDA approved Parkinson's Therapeutic Found Effectiive in Treatment of Cancer

Carbidopa is an FDA approved drug currently used in combination with Levo-Dopa to treat Parkinson’s disease. Carbidopa, itself, has no effect on Parkinson's patients, but by increasing the availability of Levo-dopa in the brain enhances the effectiveness of the drug in patients. As such, these two drugs are always prescribed together. Researchers...

Published: 12/10/2018 | Inventor(s): Vadivel Ganapathy, Yangzom Bhutia, Babu Ellappan, Sabarish Ramachandran

Keywords(s):

Category(s): Cancer Therapeutics, Pharmaceutical

Development of a Phenotypic High-Content Assay to Identify Pharmacoperone Drugs for the Treatment of Primary Hyperoxaluria Type 1 by High-Throughput Screening

Hyperoxalosis is a deadly disease for which the best current therapy is dialysis or organ transplant. The underlying cause of some forms of the disease is the misrouting of a specific enzyme; alanine:glyoxylate aminotransferase (AGT) to the mitochondira inststead of the peroxisome. Pharmacoperones are small molecules that can restore proper function...

Published: 7/2/2018 | Inventor(s): Michael Conn

Keywords(s):

Category(s): Pharmaceutical, Assay

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