Search Results - michael+conn

2 Results

Sort By:

V2 Pharmacoperone

This invention reports pharmacoperones for their novel use of therapeutics in the treatment of nephrogenic diabetes insipidus (NDI). Pharmacoperones are small molecules that enter the cell and serve as a scaffolding to allow mutated proteins to route correctly. In NDI, there is a mutation in the V2 receptor protein. Here, the inventor has reported over...

Published: 7/2/2018 | Inventor(s): Michael Conn

Keywords(s):

Category(s): Cancer Diagnostics

Development of a Phenotypic High-Content Assay to Identify Pharmacoperone Drugs for the Treatment of Primary Hyperoxaluria Type 1 by High-Throughput Screening

Hyperoxalosis is a deadly disease for which the best current therapy is dialysis or organ transplant. The underlying cause of some forms of the disease is the misrouting of a specific enzyme; alanine:glyoxylate aminotransferase (AGT) to the mitochondira inststead of the peroxisome. Pharmacoperones are small molecules that can restore proper function...

Published: 7/2/2018 | Inventor(s): Michael Conn

Keywords(s):

Category(s): Pharmaceutical, Assay