Search Results - Vaccines

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New self-attenuated prophylactic and therapeutic vaccines against microbial pathogens such as influenza viruses.

Technology SummaryTypically live-attenuated viruses alter the viral genome by deletions or mutations that render the virus inert. This is a live-attenuated vaccine for influenza that incorporates microRNA's into the viral genome to attenuate viral replication. This is shown to be beneficial for several reasons including: a robust immune response, another...

Published: 9/18/2018 | Inventor(s): Mingtao Zeng, Ke Wen

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Category(s): Vaccines, Life Sciences-> Vaccines, Immunology, Life Sciences, Therapeutics

Development of Virus like particle (VLP) vaccine and reporter assay for ZIKA virus

The Zika virus outbreaks throughout the world have prompted an immediate need for a vaccine. Currently, there is not an approved vaccine to treat Zika and application of DNA based vaccines has posed severe risks, such as insertional mutagenesis. Due to these threats, the FDA is unlikely to approve DNA based vaccines.This invention has identified a...

Published: 11/29/2018 | Inventor(s): Himanshu Garg, Anjali Joshi

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Category(s): Therapeutics, Assay, Vaccines

A novel method for producing hollow exine shells from pollen grains

Pollen grains are naturally occurring microcapsules produced by plants. Hollow pollen shells have been found useful for pharmaceutical drug delivery among other uses. To be of use for these purposes, pollen shells must be emptied of their proteinaceous material. The conventional method uses an organic solvent to defatten the pollens, then applies an...

Published: 7/2/2018 | Inventor(s): Harvinder Gill, Shashwati Atwe, Pedro Gonzalez-Cruz

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Category(s): Vaccines, Therapeutics

Post Exposure Vaccination for Anthrax using siRNA

Anthrax is a disease that rarely occurs naturally in humans, making it more realistic to develop a post exposure prophylaxis or therapy instead of a program of mass immunization. When the bacteria Bacillus anthracis is introduced into the body, it will later produce the anthrax toxin which affects certain receptors on the host’s cells, potentially...

Published: 11/29/2018 | Inventor(s): Mingtao Zeng

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Category(s): Vaccines

New live attenuated viral vaccine created by self-attenuation with species-specific artificial microRNA

The technology proposes a solution to the potential risks of the current Live Attenuated Influenza Vaccines (LAIV) by proposing a new mammalian-specific LAIV. This was done through the creation of a genetically-engineered influenza virus, that produces an immune response only in mammals. This attenuated vaccine produces mature and functional artificial...

Published: 11/29/2018 | Inventor(s): Mingtao Zeng, Junwei Li

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Category(s): Vaccines

Immunomodulation Using Spores and Pollen Grains

This technology provides that pollen grains and plant spores can be very effective biomaterials for achieving oral vaccination. Oral vaccination continues to be one of the ’holy grails’ in the field of vaccinology. Oral vaccination is needle-free, child friendly, convenient, painless, amenable to self-administration, and is safer because...

Published: 11/19/2018 | Inventor(s): Harvinder Gill, Shashwati Atwe, Yunze Ma

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Category(s): Vaccines

A Microneedle-mediated and Nanoparticle Adjuvanted Skin Patch Genetic Vaccine against Botulism

A pain-free, easily administered and stored vaccine for protection against botulism has been developed. Administration, through the skin, using a micro-needle elicits a stronger immune response than commonly used, and frequently painful, intramuscular injections. The use of a DNA plasmid makes the vaccine quick and simple to manufacture. Together, the...

Published: 7/2/2018 | Inventor(s): Mingtao Zeng, Zhengroung Cui, Amit Kumar, Junwei Li

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Category(s): Vaccines

A New Universal Influenza Vaccine

Contemporary vaccination against the influenza virus has the distinct limitation of transient effectiveness due to the phenomenon of periodic antigenic shift by which the virus mutates to outpace vaccination. However, by targeting a different, more conserved (unchanging) area of the virus, a universal vaccine may be produced that does not need to be...

Published: 11/29/2018 | Inventor(s): Mingtao Zeng, Junwei Li

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Category(s): Vaccines

Influenza Vaccine Based on Synthesized Particles

This synthetic flu vaccine, which uses gold nanoparticles as the platform, does not need to be adapted annually, like existing influenza vaccines. Furthermore, it has the potential to be a universal vaccine. Influenza vaccines have to be adapted every flu season to follow the shifts of the two antigenic membrane proteins expressed on influenza A viruses:...

Published: 7/2/2018 | Inventor(s): Harvinder Gill, Wenqian Tao

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Category(s): Vaccines