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Broad Spectrum Vaccine against Influenza and Anthrax

Influenza virus is a prominent seasonal pathogen with the potential to break out into pandemic disease. Despite the availability of current seasonal influenza vaccines, the virus mutates rapidly and necessitates annual re-formulation of vaccines. Anthrax, conversely, is a disease that may be prevented with a single regimen of anti-anthrax vaccine...

Published: 12/13/2018 | Inventor(s): Mingtao Zeng, Maria Arevalo, Junwei Li

Keywords(s):

Category(s): Life Sciences-> Vaccines

RNAi-based New Therapeutic Strategies against Anthrax

This therapeutic strategy is directed to the use of small interfering RNAs that target host factors, namely anthrax toxin receptors ANTXR1 and ANTXR2. The reduction of expression of ANTXR1 and ANTXR2 leads to the inhibition of endocytosis of anthrax toxins, which is a significant part of the toxicity mechanism. Furthermore, this strategy uses RNA interference...

Published: 12/13/2018 | Inventor(s): Mingtao Zeng, Maria Arevalo

Keywords(s):

Category(s): Therapeutics