Search Results - biomarker

2 Results

Sort By:

A biocompatible particle to detect and confirm molecules reactive against the peptide/HLA complex and HLA class I/II molecules

The human leukocyte antigen (HLA) is composed of class I and II complexes, which are expressed by nucleated cells in the body. The HLA class system uses specific peptides in order to inform the immune system of the cell's health status. In the case of an abnormal event (e.g., cancer), immunologically-related molecules such as antibodies or lymphocytes...

Published: 7/2/2018 | Inventor(s): Jon Weidanz, Devin Lowe, Oriana Hawkins

Keywords(s): Antibody, Biomarker, Biotech, Diagnostics, Immunology, polymers

Category(s): Immunology

Mechanism of the Ineffectiveness of Panabinostat against Pancreatic Cancer (Solid Malignancies) and Strategies to Increase its Efficacy

Emerging evidence suggests that histone deacetylase inhibitors (HDACi) play a significant role in cancer treatment by allowing for the expression of a tumor suppressant gene. However, the inventors have discovered that HDACi also up-regulates the expression of Bcl2 protein, which leads to resistance to chemotherapy in almost every tumor model. Therefore,...

Published: 7/2/2018 | Inventor(s): Sanjay Srivastava, Srinivas Boreddy

Keywords(s): Anti-inflammatory, Biomarker, Cancer, Gastrointestinal, integrin mediated cell signaling, nutraceuticals, Therapeutics

Category(s): Cancer Therapeutics