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Mechanism of the Ineffectiveness of Panabinostat against Pancreatic Cancer (Solid Malignancies) and Strategies to Increase its Efficacy

Emerging evidence suggests that histone deacetylase inhibitors (HDACi) play a significant role in cancer treatment by allowing for the expression of a tumor suppressant gene. However, the inventors have discovered that HDACi also up-regulates the expression of Bcl2 protein, which leads to resistance to chemotherapy in almost every tumor model. Therefore,...

Published: 7/2/2018 | Inventor(s): Sanjay Srivastava, Srinivas Boreddy

Keywords(s): Anti-inflammatory, Biomarker, Cancer, Gastrointestinal, integrin mediated cell signaling, nutraceuticals, Therapeutics

Category(s): Cancer Therapeutics