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Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells

Technology SummaryThe use of EGFR inhibitors in the treatment of NSCLC is well established, even being used as a first-line treatment for certain drugs like Gefitinib and Osimertinib. However, eventual drug-resistance by the tumor to these treatments remains a problem. This technology showcases how CRM1 inhibitor Leptomycin B can potentiate the EGFR...

Published: 9/17/2018 | Inventor(s): Weimin Gao, Zhongwei Liu

Keywords(s):

Category(s): Cancer Therapeutics

CRM1 inhibitors as an adjuvant therapy for lung cancer

Lung cancer is the leading cause of cancer deaths worldwide, in part because of chemo-resistance. Using a combination therapy with a novel CRM1 inhibitor has shown to prolong survival for lung cancer. Research has shown very low doses of the inhibitor administered with traditional chemotherapeutic agents reduce toxicity effects compared to other treatments,...

Published: 7/2/2018 | Inventor(s): Weimin Gao

Keywords(s):

Category(s): Cancer Therapeutics