Search Results - paul+trippier

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Highly Selective AKR1C3 Inhibitors and Methods of Use Thereof

The enzyme, aldo-keto reductase family 1-member C (AKR1C3), is a well-known contributor to prostate cancer, acute myeloid leukemia, and chemotherapeutic resistance. However, current inhibition research has only identified compounds with an insufficient degree of selectivity for AKR1C3 over its other isoforms.This invention has established a method...

Published: 12/10/2018 | Inventor(s): Paul Trippier, Kshitij Verma, Trevor Penning, Tianzhu Zang

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Category(s): Cancer Therapeutics

Pharmacophore elucidatin of phosphodynine A - Potent and selective Peroxisome Prolferator-Activated Receptor agonists with neuroprotective activity

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear hormone receptors and ligand-activated transcription factors that play significant roles in cellular processes. Some isoforms have been validated as therapeutic targets in certain diseases. The role of isoform PPARdelta has not yet been fully explored due to its ubiquitous expression....

Published: 7/2/2018 | Inventor(s): Paul Trippier, Paul Webb

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Category(s): Life Sciences