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Highly Selective AKR1C3 Inhibitors and Methods of Use Thereof

The enzyme, aldo-keto reductase family 1-member C (AKR1C3), is a well-known contributor to prostate cancer, acute myeloid leukemia, and chemotherapeutic resistance. However, current inhibition research has only identified compounds with an insufficient degree of selectivity for AKR1C3 over its other isoforms.This invention has established a method...

Published: 12/10/2018 | Inventor(s): Paul Trippier, Kshitij Verma, Trevor Penning, Tianzhu Zang

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Category(s): Cancer Therapeutics