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Method to Enhance Treatment of Metastatic Melanoma with BRAF Inhibitors

Malignant melanoma is the most lethal form of skin cancer and accounts for almost 80% of skin cancer deaths. About 60% of melanomas have a mutation in the BRAF oncogene at V600E. The FDA recently approved (January 2014) the combination of a BRAF inhibitor (Dabrafenib) and a MEK 1/2 inhibitor (Trametinib) to treat this type of melanoma. A problem...

Published: 7/2/2018 | Inventor(s): Sanjay Srivastava, Neel Fofaria

Keywords(s): Cancer, Medicine, Molecular Medicine, Therapeutics

Category(s): Cancer Therapeutics, Pharmaceutical, Therapeutics

Use of Thioredoxin or thioredoxin-like molecules, peptides for treatment of high blood pressure

A natural protein has been discovered that is effective in controlling blood pressure. Overexpression of the protein was found to lower blood pressure and inhibit the induction of angiotensin II mediated hypertension in mice. Further study showed that the mice, while treated with angiotensin II, had significantly higher relaxation of the mesenteric...

Published: 9/12/2018 | Inventor(s): Kumuda Das

Keywords(s): Biotech, Blood Pressure, Cardiovascular, Medicine, Pulmonary hypertension

Category(s): Therapeutics

Self-Deployed Cuff and Skirt Tracheal Tube

The invention is a self-deployed endotracheal tube using a combined cuff and skirt approach that solves many of the problems associated with traditional endotracheal tubes. This invention replaces the inflation conduit with a hole connecting the inside of the tracheal tube to the inside of the cuff. It also includes a deployable skirt just proximal...

Published: 9/5/2018 | Inventor(s): Bradley Fuhrman

Keywords(s): Biotech, Medicine

Category(s): Medical Device

Overcoming Vemurafinib Resistance in Metastatic Melanoma by inhibiting Mcl-1

Malignant melanoma is the deadliest form of skin cancer, accounting for seventy-five percent of skin cancer related deaths. Until recently, treatment options for late stage metastatic cancer had been limited. In 2011, the FDA approved vemurafenib, a BRAF inhibitor, for the treatment of late stage metastatic cancer that bears the BRAF oncogene. Patients...

Published: 7/2/2018 | Inventor(s): Sanjay Srivastava, Neel Fofaria

Keywords(s): Cancer, Medicine

Category(s): Cancer Therapeutics