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Tunable nanocomplexes for delivery of plasmid DNA into human and vertebrate primary cells

Historically, poly(D,L-lactide-co-plycolide) (PLGA) complexes with polyethylenimine (PEI) coated surfaces have been used as a DNA delivery mechanism in gene therapy. This allows for a complex that has relatively low cytotoxicity, binds DNA, and has a cationic surface to allow for easy entry into the target cell. However, these complexes still maintain...

Published: 12/11/2018 | Inventor(s): Huanyu Dou

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Category(s): Genomics, Nanotechnology