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Disulfiram is a Direct and Potent Inhibitor of MGMT in Brain Tumor Cells

MGMT is a DNA repair protein that interferes with the cytotoxic action of alkylating chemotherapy agents. Because of the prevalence of this protein in tumors, especially brain tumors, there is a great need for the discovery of an inhibitor that will not harm bone marrow stem cells. This invention has solved this problem through the discovery of a...

Published: 12/13/2018 | Inventor(s): Kalkunte Srivenugopal, Ameya Paranjpe

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Category(s): Cancer Therapeutics